
Microorganisms, also known as microbes or germs, are living cells so small
that most can be seen only with a microscope. Any substance or mixture of
substances that acts against microbes (such as a disinfectant, sanitizer
or sterilant) is an antimicrobial agent.
Antimicrobial products help reduce the proliferation of undesirable bacteria,
fungi, algae and viruses including many that affect public health. Disinfecting
and sanitizing products protect many essential aspects of industry, institutions,
hospitals and homes.
Disinfectants and
sanitizers have been in use for over 50 years and have stood the test
of time.
Antimicrobial products
are regulated by one or more of three government agencies (EPA, FDA, USDA)
depending on their intended use. Commercial products are subjected to
extensive efficacy and toxicity testing before they can be sold.
The regulation of
antimicrobial products by the federal government is thorough and encompassing.
For instance, prior to marketing an antimicrobial product, the manufacturer
must obtain EPA registration by submitting the product label and extensive
data on chemistry, toxicology, and efficacy (effectiveness).
In antimicrobial
products, the ingredients that are effective against microorganisms are
called active ingredients. Only small quantities of biocidal actives are
required for effective control, but every microbial problem calls for
a different solution. Most products contain other substances called inert
ingredients to make the products safer and easier to handle, measure and
apply, or to make them effective for other uses such as cleaning.
The mixture of active
and inert ingredients is called the formulation. Government agencies regulate
both the active ingredient and the formulation.
In order to obtain
EPA registration, sterilants, disinfectants and sanitizers must pass a
series of rigorous efficacy tests to verify their manufacturers' claims.
Sterilants are subjected to the highest efficacy standards, followed by
disinfectants, and then sanitizers. Toxicology screening and thorough
chemical characterization are also required by EPA for each antimicrobial
active ingredient and inert ingredient.
Antimicrobial products
for hard surfaces should not be confused with agricultural pesticides
that are used to treat crop diseases or antibiotics used to treat human
and animal infections.
The increased awareness
of a link between overuse and misuse of antibiotics and the development
of resistant strains of bacteria has led to concern that similar resistant
microorganisms may develop as a result of home and institutional use of
antimicrobial surface cleaners. There is no basis for this concern as
the phenomenon has never been observed in these environments.
Drug resistance in
bacteria does not imply any increased hardiness of the organism or increased
resistance to general disinfectants. The same disinfectants will still
work for drug-resistant strains.
Drug-resistant bacteria
resulting from misuse of antibiotics is an emerging public health issue.
There is currently no evidence that resistance to disinfectant products
occurs as a result of their use in home or institutional settings.
Disinfectants and
sterilants used in health care are literally life savers. They destroy
harmful bacteria, viruses, spores and fungi which affect public health.
Disinfectants are
important tools in fighting disease in the home and at work. They break
a link in the chain of events that leads to infection by killing or reducing
disease-producing microorganisms on environmental surfaces and objects
or when used in antimicrobial (antiseptic) soaps for skin application.
Further evidence
of the effectiveness of antimicrobial products is seen in a study and
intervention program in a New York child-learning center that focused
on disease transmission and the regular use of disinfectants. The results
showed a 24 percent reduction in overall infections and 37 percent reduction
in respiratory illness among the children during the intervention period.
As a result, days missed from school due to respiratory illness, physician
visits and course of prescribed medication also declined.
Recommendations for
the use of home mixtures as alternatives to disinfectants or sanitizers
are based on the misperception that commercially formulated products are
inherently hazardous. They ignore the extensive efficacy and toxicity
testing that form the basis for the safe and effective use of commercial
products, when used according to label directions. The use of ineffective
home mixtures instead of disinfectants can lead to serious health risks.
Antimicrobial substances
that are added to various products and materials to prevent contamination
and deterioration are called preservatives. Without preservatives, microbial
contamination would cause widespread and costly spoilage of products such
as household cleaners, detergents, paints, cosmetics, pharmaceuticals
and wood fibers.
Benefits derived
from the use of antimicrobial agents in an industrial environment are
predominantly economic. The largest industrial use of antimicrobials is
to render drinking water free of disease producing contamination and eliminate
off-taste and odor.
Continuing incidents
of food poisoning demonstrate the uncertainty of some food sanitation
practices and the importance of antimicrobials in the maintenance of the
safety of our food supply.
|